发明名称 |
PROSTAGLANDINE DERIVATIVES FOR THE TREATMENT OF DISEASES WITH BONE MASS LOSS HAVING EP4 AGONIST ACTIVITY AND PHARMACEUTICAL COMPOSITIONS THEREOF |
摘要 |
A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
|
申请公布号 |
HU0600140(A2) |
申请公布日期 |
2007.08.28 |
申请号 |
HU20060000140 |
申请日期 |
2002.07.22 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
MARUYAMA, TORU;KOBAYASHI, KAORU;KAMBE, TOHRU;MARUYAMA, TAKAYUKI;YOSHIDA, HIDEYUKI;NISHIURA, AKIO;ABE, NOBUTAKA |
分类号 |
A61K45/00;A61K31/559;A61P19/08;A61P19/10;C07C405/00;C07D207/24;C07D207/27;C07D263/24 |
主分类号 |
A61K45/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|