PHARMACOLOGICAL ACTIVE AMIDES, MANUFACTURE AND PHARMACOLOGICAL COMPOSITION

摘要

Amides of formula: I in which A is V and W are H, halogen, alkyl (1-3C), alkoxy (1-3C), NO2 or CF3, Z is bound in the ortho or para position with respect to B and is phenyl, optionally substituted, thienyl or pyridyl, the chain X-(CH2)n-(CHR)m-CO-NR1R2 is bound in the ortho or para position with respect to B, R is H or alkyl (1-3C), R1 and R2 are alkyl (1-6C), cycloalkyl (3-6C), phenyl, phenylalkyl, cycloalkylalkyl, alkenyl (3-6C), R1 and R2 can also form, with the nitrogen atom to which they are attached, a pyrrolidine, piperidine, morpholine or thiomorpholine ring, X is >CH-R3, >N-R4, >SO, >SO2, >O or >S, R3 is H, alkyl (1-3C), R4 is alkyl (1-3C) m=0 or 1 and n=0, 1 or 2, provided that, if X is >SO, >SO2 or >N-R4, the sum m+n is equal to at least 1, that, when A and B are N and Z is in the para position with respect to B, X cannot denote the group >CH-R3 and that when A is CH, B is N, Z is in the ortho position with respect to B, X is an oxygen atom, and R is a hydrogen atom, the sum m+n is other than 1, and excluding 2-phenyl-4-quinolyl N,N-dimethylcarbamate, have useful pharmacological activity, e.g. as anxiolytics, anticonvulsants and antiangina agents.