| 摘要 |
NEW MATERIAL:The compound of formula I (R is electron-attractive organic group; X<-> is anion; n is 1-6). EXAMPLE:4-( 4-Amino-4-carboxybutyl )-1-( 5-amino-5-carboxypentyl-5- ( 3-amino-3- carboxypropyl)-3-[3-carboxy-3-{ 3-(2-pyridyldithiopropionyl }amino] propylpyri dinium acetate. USE:Reagent for the preparation of artificial antigen. PREPARATION:Desmosine or its salt is made to react with an activated carboxylic acid of formula II (A is ethoxy, group, of formula III, etc.) at a molar ratio or 1:1.05 at 15-20 deg.C for 1-5hr to obtain the objective compound. It is essential to carry out the reaction in a phosphate buffering solution at 5.0-6.5pH. |
