| 摘要 |
NEW MATERIAL:A compound shown by the formula I (X is CH or N; R is carboxyl, lower alkyl, OH, aryl, etc.; Y is H, lower alkyl, lower alkoxy, halogen, etc.) EXAMPLE:4-[2-(3-Trifluoromethylanilino)benzylidenamino}phenylace-tic acid. USE:An anti-inflammatory drug having extremely low side effects such as gastriointestinal disorder and extremely long half-life period of blood, showing long-time acting effects. PREPARATION:An aldehyde shown by the formula II is reacted with an amine shown by the formula III in an organic solvent such as ethanol, etc., at room temperature - under heating at <=300 deg.C for 0.5-24hr to give a compound shown by the formula I. 1mol compound shown by the formula II is reacted with 1-3mols compound shown by the formula III. |
