| 摘要 |
NEW MATERIAL:A thiourea derivative shown by the formula I (X is CH or N; Y is H, halogen or lower alkoxy; R<1> is H, lower alkyl, substituted benzyl, alkylthioalkyl, mercaptoalkyl, hydroxyalkyl, alkoxycarbonylalkyl or indolylmethyl; R<2> is lower alkyl). EXAMPLE:N-1-Isopropyl-1-methoxycarbonylmethyl-N-nicotinoylthio urea. USE:A drug having excellent suppressive action on inflammations, asthma and hypertension, blood sugar lowering action and inhibitory action on blood platelet aggregation and an agricultural and horticultural agent having antifungal action, sterilizing action, insecticidal action and herbicidal action and improved characteristics with respect to toxicity. PREPARATION:A compound shown by the formula II is reacted with a compound shown by the formula III in an organic solvent such as acetone preferably at 40-160 deg.C and the reaction product is reacted with a compound shown by the formula IV under the same condition as that of the above-mentioned reaction, to give a compound shown by the formula I. |
