| 摘要 |
NEW MATERIAL:The compound of formula I (R<1> is substituted or unsubstituted phenyl; R<2> is H or lower alkyl; R<3> is H, lower alkyl or lower alkanoyl; Q is single bond or lower alkylene; Alk is lower alkylene; Y and Z are O or S; the group of formula II is formula III or formula IV) or its salt. EXAMPLE:N-methyl-2-{2-[2-(4-(3-fluorophenyl-1,2,3,6-tetrahydro-py-ridi n-1-yl)ethyl oxy]phenyl}thiazolidine-3-carbothioamide-. USE:It has long-acting cardiotonic activity and is useful for the remedy and prevention of congestive cardiopathy. PREPARATION:The compound of formula I can be produced by reacting the compound of formula V with the compound of formula VI or its salt in a proper solvent in the presence or absence of an acid acceptor (e.g. sodium hydroxide). |
