| 摘要 |
Solid, stable dosage forms consisting of a moisture- and temperature-sensitive core prepared from a medicament, or a mixture of medicaments, and excipients, and an elastic film coating which decomposes in aqueous solution, said elastic film coating substantially comprising (a) a water-soluble component consisting of 20-60% of hydroxypropyl cellulose having an average molecular weight of 75,000, and (b) a water-insoluble component consisting of 5-20% of an acrylic resin in the form of (b1) a 70:30 ethyl acrylate/methyl methacrylate copolymer having a molecular weight of 80,000, or (b2) a 30:70 to 70:30 methyl acrylate/methyl methacrylate copolymer having an average molecular weight of 500,000, 20-60% of a lubricant, 0.5-5% of a wetting agent, 0-5% of a plasticizer, and optional additional excipients, and process for the preparation thereof. |
