发明名称 |
6(R)-(2-(8'-ETHERIFIED-HYDROXY-2',6'-DIMETHYLPOLYHYDRO-NAPHTHYL-1')-ETHYL)-4(R)-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONES,THE HYDROXY ACID FORM OF SAID PYRANONES,THE SALTS OF SAID ACID FORM,PROCESS FOR PREPARING THE SAME AND AN ANTIHYPERCHOLESTEROLEMIC PHARMACEUTICAL COMPOSITION CONTAINING THE SAME |
摘要 |
<p>6(R)-[2-(8'-Etherified-hydroxy-2',6'-dimethylpolyhydronaphthyl-1')-eth yl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones are prepared from the corresponding 8'-acyloxy compounds, some of which are naturally occurring, by protection of the 4(R)-hydroxyl and the 2-keto group, followed by reductive removal of the 8'-acyloxy group, etherification of the resulting 8'-hydroxyl and removal of the protecting groups. The products inhibit the biosynthesis of cholesterol.</p> |
申请公布号 |
IE51476(B1) |
申请公布日期 |
1987.01.07 |
申请号 |
IE19810000167 |
申请日期 |
1981.01.29 |
申请人 |
MERCK & CO.,INC. |
发明人 |
|
分类号 |
C07C59/62;C07D309/30;C07F7/18;(IPC1-7):C07C59/62 |
主分类号 |
C07C59/62 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|