2-SUBSTITUTED-3-SULFONAMIDEPYRIDINE COMPOUNDS, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

摘要

2-substituted-3-sulfonamidepyridine compounds of the formula …… are disclosed wherein R1 and R2 represent a hydrogen atom or a lower alkyl group; R3 and R4 are hydrogen atoms or else form a five membered-ring with two substituents R5R6 &ldurule& , wherein R5 and R6 are independently hydrogen atoms, lower alkyl groups, phenyl or heteroaryl groups, which substitution is optional, and X represents an oxygen atom or a &rdurule& N-R7 group, R7 being a C1-C6 alkyl group preferably branched out, e.g., with isopropyl, isobutyl, t-butyl, isoamyl, t-amyl, neopentyl groups. Those compounds are useful as hypotensives and as alpha and beta adrenergic blocking drugs as well as intermediates in the synthesis of other pharmacologically active pyridines. A process for preparing said derivatives is also described.