Isoquinolinesulfonamide derivatives

摘要

This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): <IMAGE> (I) wherein A is a C0-10 alkylene group or a C0-10 alkylene group having a C1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R1 and R2 each is a hydrogen atom; or R1 and R2 are linked directly to form an ethylene group unsubstituted or substituted with a C1-4 alkyl group; R3 and R4 each is a hydrogen atom, a C1-6 alkyl group or linked directly to form a C2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.