| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: method ensures carrying out aldole condensation in presence of epoxide mesilate and tosilate, using auxiliary chiral sultamic group as carboxyl- protecting group, as a result, reduction and oxidation stages, requiring extra time, before carrying out final stage of macrolactonisation are excluded. Introduction of epoxidic group at early stages of method allows also excluding stage of epoxilation of more complex intermediate compounds at further stages of process. ^ EFFECT: high reproducibility of synthesis of highly-purified epothilone derivatives. ^ 8 cl, 6 ex |
