| 摘要 |
PURPOSE:An agent, containing human erythropoietin as an active constituent and useful as a remedy for renal anemia. CONSTITUTION:A remedy containing human erythropoietin as an active constituent. The erythropoietin (hereinafter abbreviated to EPO) is a glycoprotein mainly produced in the kidney and a humoral hematopoietic factor having action of affecting erythroblastic stem cells present in marrow to promote the differentiation to erythrocytic cells, but is effective for serious anemia in patients with renal insufficiency, particularly patients undergoing dialysis. The human EPO can be obtained by various means. Examples thereof include methods of purification from human urine, gene expression of a gene coding amino acid sequence of the human EPO in a host cell, e.g. Escherichia coil, yeast, Chinese hamster, ovarian cell, COS cell, etc. The remedy is normally administered by a method for administering the human EPO pharmaceutical containing 0.1-500mug EPO per adult 1-7times/week. |
