METHODS FOR THE TREATMENT, PREVENTION AND DIAGNOSIS OF LIPID METABOLISM ASSOCIATED DISEASES

摘要

The present invention discloses the identification of genes related to lipid metabolism, more particularly genes which are modulated in the absence of apolipoprotein A1 (ApoA1). Thus, the present invention provides 1) screening methods for the identification of compounds that modulate the activity and/or expression level of more or more high-densitv lipoprotein cholesterol ( HDLc) related genes or encoded proteins identified herein; 2) methods of treating or preventing lipid metabolism associated diseases; 3) diagnostic methods and kits for detecting a predisposition to lipid metabolism associated diseases and disorders; 4) animal models for identifying compounds for treating, preventing or decreasing susceptibility to a lipid metabolism associated disease or a HDL-metabolism disease; and 5) HDLc related genes and encoded proteins.