| 摘要 |
PURPOSE:A pharmaceutical preparation having uniform color tone of appearance, proper strength and improved stability, obtained by adding a neutral salt to a combined drug of sodium guaiazulenesulfonate (GAS-Na) and L-glutamic acid (L-Glu). CONSTITUTION:A medicinal component consisting of GAS-Na having inhibitory action on histamine liberation, anti-inflammatory action, tissue regenerating action, etc., and L-Glu having antitumor action is blended with 15-100pts.wt., preferably 20-70pts.wt. based on 100pts.wt. GAS-Na of a neutral salt such as ammonium chloride, sodium chloride, calcium sulfate, etc. Further addition of a hindered phenolic stabilizer (e.g., butylhydroxytoluene) improves stability of the medicinal component. Preferably powder of the three components is kneaded with water and an organic solvent (e.g., acetic ester, etc.) having <=0.005wt% GAS-Na solubility and pharmaceutically manufactured. |
