发明名称 |
Process for producing 5-fluorouracil |
摘要 |
A process for producing 5-fluorouracil using an aqueous phosphoric acid solution as a solvent which is a good solvent for an intermediate resulting from the reaction between uracil and elemental fluorine, and permits the reaction to proceed smoothly, but which can precipitate the final product, 5-fluorouracil, after cooling the heat-treated reaction solution to room temperature, with no need to evaporate the solvent. The process comprises reacting uracil in an aqueous phosphoric acid solution with elemental fluorine and heating the resultant reaction solution to form 5-fluorouracil.
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申请公布号 |
US4631342(A) |
申请公布日期 |
1986.12.23 |
申请号 |
US19850709284 |
申请日期 |
1985.03.07 |
申请人 |
ONODA CEMENT COMPANY, LTD.;SAGAMI CHEMICAL RESEARCH CENTER |
发明人 |
UMEMOTO, TERUO;OGURA, EIJI |
分类号 |
C07D239/54;C07D239/553;(IPC1-7):C07D239/22 |
主分类号 |
C07D239/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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