TROPYL AND PSEUDOTROPYL ALKYL-BENZOATES AND THEIR USE IN MIGRAINE TREATMENT

摘要

TROPYL AND PSEUDOTROPYL ALKYL-BENZOATES AND THEIR USE IN MIGRAINE TREATMENT Migraine is treated with a pseudotropyl or tropyl benzoate derivative of the following general Formula I: < IMG > wherein:- Ar represents < IMG > n represents O or an integer from 1 to 3 R1 represents C1-C4 alkyl; R2 represents C1-C4 alkyl, C1-C4 alkoxy or halogen provided that R2 is the same as R1 when n is 2 or 3; and R3 and R4 independently represent hydrogen, C1-C4 alkyl, C1-C4 alkoxy, or halogen provided that for tropyl derivatives R3 is alkyl and R4 is hydrogen; or a pharmaceutically acceptable salt thereof. With the exception of tropyl-2-methylbenzoate, the derivatives of Formula I are novel compounds.