Low dose-rate radiation for medical and veterinary therapies with three dimensionally shaped profiles

摘要

Various embodiments relate to a method of performing microbeam radiation therapy (microbeam radiosurgery) for a subject, including: producing a high-energy radiation beam; shaping, attenuating, strengthening, hardening and/or otherwise appropriately modifying the high-energy radiation beam using a low-Z, high-Z, or variable-Z filter; passing the beam before or after it has been so modified through a collimator to produce high-dose regions alternating with low-dose regions; and irradiating the subject with the collimated beam so modified.

主权项

1. A method of performing microbeam radiation therapy for a subject, comprising:
producing a high-energy radiation fan beam, wherein the width of the fan beam in a first direction is greater than the width of the fan beam in a second direction; shaping the fan beam; and producing a relative movement between the subject and the fan beam to irradiate the subject through a collimator to produce high-dose regions alternating with low-dose regions, wherein the collimator is affixed to the subject.