发明名称 |
INHIBITORS OF THE T CELL-SPECIFIC ALTERNATIVE P38 ACTIVATION PATHWAY AND METHODS OF USE |
摘要 |
In T lymphocytes, p38 mitogen activated protein kinase (MAPK) can be activated through an alternative pathway that involves phosphorylation at tyrosine 323. Disclosed herein is the identification of a minimal region of the growth arrest and DNA damage-inducible alpha (Gadd45α) protein that is required for binding to and inhibition of tyrosine 323-phosphorylated p38 in T cells. The disclosed Gadd45α polypeptides inhibit proliferation of T cells in response to T cell receptor stimulation, inhibit differentiation of T cells into Th1 or Th17 cells, inhibit the production of proinflammatory cytokines, and reduce tumor formation and growth of inflammatory cancers, such as pancreatic cancer. |
申请公布号 |
EP2922865(A4) |
申请公布日期 |
2016.06.29 |
申请号 |
EP20130857490 |
申请日期 |
2013.11.19 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
ASHWELL, JONATHAN, D.;ALAM, MUHAMMAD, S. |
分类号 |
C07K7/08;A61K38/10;A61P37/00;C07K14/47;C07K19/00 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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