摘要 |
<p>A process for preparing a polypeptide represented by H-X-Pro-Y-OH (wherein X represents an amino acid other than Pro, and Y represents a peptide chain), which comprises reacting aminopeptidase with a polypeptide represented by H-Met-X-Pro-Y-OH (wherein X and Y are as defined above). This process enables to specifically remove methionine at the amino terminal of the polypeptide. Therefore, polypeptides of a natural amino acid sequence can be produced with industrial advantage from polypeptides produced, for example, by genetic engineering technology.</p> |