5-Substituted pyrazolo¬4,3-d pyrimidine-7-ones, process for preparing the compounds and pharmaceutical compositions comprising the compounds

摘要

The present invention relates to novel 5-substituted pyrazolo[4,3-d]pyrimidine-7-one compounds of formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="34" wi="67" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and compositions, methods of use and processes to make the compounds. The novel compounds are useful in the treatment of cardiovascular disorders, such as heart failure or cardiac insufficiency, The novel compounds bind adenosine receptors and selectively inhibit phosphodiesterase.