| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R1 and R2 are H or 1-6C alkyl; R3 is 1-6C alkyl; R1 and R3 may form a ring; R4 is 1-6C alkyl, alkoxy or halogen). EXAMPLE:6-Amidino-2-naphthyl- 2-methoxy-4-[4,5-dihydro-1H-imidazol-2-yl)-amino]-benzoate-. USE:An antitrypsin agent, antiplasmin agent, antikallikrein agent and antithrombin agent, useful for treating pancreatitis, hemorrhagic diseases, thrombosis, etc., having powerful C1 esterase inhibitory action and complement hemolysis inhibitory action and useful as an anticomplement agent effective for allergic diseases, e.g. nephritis. PREPARATION:A carboxylic acid compound expressed by formula II or a reaction intermediate thereof is reacted with 6-amidino-2-naphthol expressed by formula III, preferably an acid addition salt thereof in a solvent, e.g. pyridine, at -30-+80 deg.C to afford the aimed compound expressed by formula I.
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