| 发明名称 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases | ||
| 摘要 | Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | ||
| 申请公布号 | US9428743(B2) | 申请公布日期 | 2016.08.30 |
| 申请号 | US201514684052 | 申请日期 | 2015.04.10 |
| 申请人 | aTyr Pharma, Inc.;Pangu BioPharma Limited | 发明人 | Greene Leslie Ann;Chiang Kyle P.;Hong Fei;Vasserot Alain Philippe;Lo Wing-Sze;Watkins Jeffry D.;Quinn Cheryl L.;Mendlein John D. |
| 分类号 | C07K16/40;G01N33/573;A61K38/16;A61K38/00;C12N9/00 | 主分类号 | C07K16/40 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP |
| 主权项 | 1. A pharmaceutical composition comprising an isolated polynucleotide that encodes a tyrosyl-tRNA synthetase (TyrRS) polypeptide of up to about 260 amino acids in length and comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 34 or 36, wherein the isolated polynucleotide is selected from the group consisting of (a) a cDNA polynucleotide, and (b) a modified mRNA polynucleotide; wherein the polypeptide has an extracellular signaling activity; and wherein the composition is substantially endotoxin-free. | ||
| 地址 | San Diego CA US | ||