Acid ceramidase inhibitors and their use as medicaments

摘要

The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant.

主权项

1. A compound of Formula Ib or pharmaceutically acceptable salt thereof wherein A represents O; Y represents C1-C8 alkyl; W represents hydrogen; R1 represents hydrogen; R2 represents trifluoromethyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, or a group selected from O—R6 and NR7R8; R3 represents hydrogen; R6 represents an optionally substituted C1-C8 alkyl; and R7 and R8 independently represent hydrogen, an optionally substituted C1-C6 alkyl, a group (C═O) aryl, or, when taken together with the nitrogen atom to which they are bound, an optionally substituted heterocyclyl.