| 摘要 |
NEW MATERIAL:A compound expressed by formula I [R<1> is formula II (R<6> is H, halogen, alkyl or nitro), etc.; R<2>-R<4> are H or alkyl; R<5> is formula III (R<7> is alkyl or cycloalkyl), formula IV (X is S, N or O), etc.; m and n are 0, 1 or 2] and an acid addition salt thereof. EXAMPLE:N-(4-tert-Butylbenzyl)-N-methyl-3-benzothiophene methylamine. USE:An antifungal agent capable of exhibiting improved anifungal activity particularly against Trichophyton mentagroiphytes, Trichophyton interdigitale, etc. PREPARATION:A compound expressed by formula V (A is eliminative group) is reacted with a compound expressed by formula VI to give the aimed compound expressed by formula I. The reaction is carried out in a solvent, e.g. benzene or dioxane, at a temperature between room temperature - the boiling point of the solvent, preferably room temperature - 60 deg.C.
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