发明名称 |
Fluorine-containing antifolates incapable of polyglutanayte formation related compounds |
摘要 |
A methotrexate derivative having the following general formula is incapable of forming polyglutamate and thus is expected to have reduced cytotoxicity associated with the formation of polyglutamate derivatives in a living cell, <IMAGE> +TR <IMAGE> wherein n is from 0 to 5.
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申请公布号 |
US4628090(A) |
申请公布日期 |
1986.12.09 |
申请号 |
US19850767122 |
申请日期 |
1985.08.19 |
申请人 |
RENSSELAER POLYTECHNIC INSTITUTE |
发明人 |
COWARD, JAMES K. |
分类号 |
C07D475/08;(IPC1-7):C07D475/08 |
主分类号 |
C07D475/08 |
代理机构 |
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代理人 |
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地址 |
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