| 摘要 |
PURPOSE:To obtain the titled compound, containing a novel compound of the same system as the naturally occurring compound and having antimicrobial activity in a large amount by the chemical synthetic method in one stage, by oxidizing 2-(2-hydroxyphenyl)-2,5-dihydrofuran with a specific oxidizing agent. CONSTITUTION:A 2-(2-hydroxyphenyl)-2,5-dihydrofuran (in which 4-methyl substitution product thereof is a well-known compound) is reacted with n-butyl lithium and converted into a metal salt, e.g. lithium salt, to increase the solubility in water. The resultant metal salt then oxidized with an oxidizing agent, e.g. an aqueous solution of potassium nitrosodisulfonate (called Fremy's salt) to afford the aimed compound, capable of existing stably at <=0 deg.C in N2 though decomposed by allowing to stand at room temperature and useful as a medicine, e.g. 2-quinoyl-4-(4-methyl-3-pentenyl)furan, particularly a 2-quinoyl-4-substituted furan. EFFECT:The raw material can also be readily synthesized.
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