CARBAPENEM COMPOUND

摘要

NEW MATERIAL:A compound expressed by formula I (R<1> is carboxy, cyano, hydroxymethyl, etc.; R<2> is H, alkyl heteroaryl, benzyl, phenyl, etc.; R<3> is H or alkyl; R<4> is H or a protecting group of the carboxy group) and a salt thereof. EXAMPLE:4-Nitrobenzyl (5R, 6S)-6-[(1R)-hydroxyethyl]-2-[(2S, 4S)-2-carbamoyl-1-[(N-4-nitrobenzyloxycarbonyl)acetimidoyl]pyrrolidin- 4-ylth-io]-2-carbapenem-3-carboxylate. USE:An antimicrobial agent. PREPARATION:A compound expressed by formula II (R<4>' has the same meaning as the protecting group in R<4>) is reacted with an anhydrous alkanesulfonic acid, etc., in the presence of a base to convert the group expressed by the formula =O into a group expressed by the formula -OR<7> (R<7> is alkanesulfonyl, etc.), and the resultant compound is then reacted with a compound expressed by formula III (R<1>' has the same meaning as R<1> which may have protected amino group; R<3>' has the same meaning as R<3> or is the protecting group of the amino group). The protecting groups are then removed to afford the aimed substance.