PHOTODYNAMIC INACTIVITY OF VIRUS IN THERAPEUTICAL PROTEIN COMPOSITION

摘要

Viruses present in therapeutic protein compositions are inactivated without substantially affecting the activity of the protein by exposing the compositon to light in the presence of a photosensitizer until the viruses are inactivated. The resulting compositions are substantially free of infectious viruses. The method is applicable to the inactivation of hepatitis and retroviruses in blood plasma protein compositions.