| 摘要 |
PURPOSE:To easily, efficiently and inexpensively produce a D-alpha-amino acid useful as an antibiotic, a germicide, etc., by treating a specific amino acid amide with a culture mixture of a bacterium belonging to the genus Pseudomonas, etc. CONSTITUTION:A mold of a bacterium belonging to the genus Pseudomonas is cultivated in a medium consisting of a carbon source, a nitrogen source, an inorganic salt, a D-alpha-amino acid, etc. at 4-10pH at 20-50 deg.C for 1-7 days to (A) give the culture mixture. 1-40wt% of (B) a D-alpha-amino acid amide shown by the formula {R is (substituted)alkyl, (substituted)phenyl, furyl, pyridyl, thiazolyl, imidazolyl, or indolyl] is reacted with 0.005-10pts.wt. based on 1pt.wt. component B of dried mold corresponding amount of the component A at 20-70 deg.C at 5-13pH, to give a D-alpha-amino acid. Then, it is separated and purified to give high-purity crystal. |
