Oxothiazolidine compound.

摘要

This invention provides a oxothiazolidine compound of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="26" wi="27" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>1</Sup> is acyl;
<UnorderedLists id="ula01" listStyle="none"><ListItem>di(lower)alkylamino(lower)alkylcarbamoyl(lower)-alkyl; arylcarbamoyl(lower)alkyl;</ListItem><ListItem>ar(lower)alkylcarbamoyl(lower)alkyl;</ListItem><ListItem>heterocyclic carbamoyl(lower)alkyl;</ListItem><ListItem>heterocyclic(lower)alkylcarbamoyl(lower)alkyl;</ListItem><ListItem>thiazolidinylcarbonyl(lower)alkyl;</ListItem><ListItem>morpholinylcarbonyl(lower)alkyl or a group of the formula :<!-- EPO <DP n="2"> --><Chemistry id="chema02" num="0002"><Image id="ia02" he="23" wi="66" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem><ListItem>in which A is lower alkylene;</ListItem><ListItem>n is an integer of 0 or 1;</ListItem><ListItem>m is an integer of 2 or 3;</ListItem><ListItem>X is -N-,<Sup>O</Sup> or -CH-and</ListItem><ListItem>-N-R<Sup>2</Sup> is hydroxy;</ListItem><ListItem>lower alkyl which may have hydroxy; ar(lower)alkyl which may have halogen;</ListItem><ListItem>arylthio which may have halogen;</ListItem><ListItem>acyl or heterocyclic group and</ListItem><ListItem>Y is
<Chemistry id="chema03" num="0003"><Image id="ia03" he="18" wi="54" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem></UnorderedLists>or pharmaceutically acceptable salt thereof.

This compound is useful as cognition activator. This invention further provides processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.