| 摘要 |
PURPOSE:To accumulate a remarkable amount of L-lysine in a culture medium containing an ordinary carbon source and obtain efficiently the L-lysine useful for medicines, etc., by cultivating a microorganism, belonging to the genus Providencia, and capable of producing the L-lysine. CONSTITUTION:A microorganism, belonging to the genus Providencia and capable of producing L-lysine, preferably Providencia rettgeri TP4-105-37 (FERM-P No. 8218), having the resistance to lysine metabolic antagonistic substances is cultivated in a culture medium to produce and accumulate the L-lysine in the culture medium. The resultant L-lysine is collected from the culture medium. The cultivation is preferably carried out at 24-37 deg.C and 5-9pH of the culture medium under aerobic conditions for 48-120hr. |
