| 摘要 |
NEW MATERIAL:A vinyl fluoride derivative shown by the formula I [A is group shown by the formula II (R<1> is alkylene), formula III, etc.; B is group shown by the formula IV (R<2> is monohydric alcohol residue or H; m is 0-5) or group shown by the formula V(X is OH, halogen or nitrile; n is 1-5)]. EXAMPLE:Ethyl 5,6-dihydroxy-2-fluoro-2-hexenoate 5,6-acetonide(3). USE:An intermediate for a fluorine-containing physiologically active substance. PREPARATION:An aldehyde shown by the formula VI is reacted with Wittig reaction shown by the formula VII (R<4> is alkyl, aryl, or aralkyl), and, if necessary, further reduced, and halogenated and/or subjected to carbon increasing reaction to give a vinyl fluoride derivative shown by the formula I.
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