发明名称 |
PROCEDIMIENTO PARA LA PREPARACION DE NUCLEOSIDOS |
摘要 |
<p>A novel process for the preparation of a conjugate of a 21-hydroxy steroid and a nucleoside-5'-monophosphate comprises reacting the 21-hydroxy steroid with a derivative of the nucleoside-5'-monophosphate (in which hydroxy groups on the carbohydrate ring are protected) in the presence of 2,4,6-triisopropylbenzene sulphonyl chloride (TPS) as a condensing agent under anhydrous conditions and removing the hydroxy protecting groups from the conjugate thereby obtained. Such conjugates and their salts are useful as anticancer and antiviral agents.</p> |
申请公布号 |
ES549558(D0) |
申请公布日期 |
1986.12.01 |
申请号 |
ES19850549558 |
申请日期 |
1985.12.04 |
申请人 |
BORYUNG PHARMACEUTICAL CO.,LTD. |
发明人 |
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分类号 |
C07H19/16;A61K31/70;A61K31/704;A61K31/7042;A61K31/7052;A61K31/706;A61K31/7064;A61K31/7072;A61K31/7076;A61P31/12;A61P35/00;C07H19/10;C07H19/12;C07H19/14;C07H19/20;C07H19/207;C07J43/00;C07J51/00;(IPC1-7):C07H19/00 |
主分类号 |
C07H19/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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