| 摘要 |
PURPOSE:To obtain chlorobenzyl-tetrahydro-thieno[3,2-C]pyridine useful as an agent for suppressing the coagulation and agglutination of platelet, by reacting tetrahydro-thieno-pyridine with a chlorobenzyl derivative in the presence of an organic tertiary amine. CONSTITUTION:The objective 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-C]pyri d-ine of formula II and its salt can be produced by reacting (A) 1 mol of 4,5,6,7- tetrahydro-thieno[3,2-C]pyridine with (B) preferably 0.5-1mol of a 2-chlorobenzyl derivative in the presence of an organic tertiary amine (preferably triethylamine or pyridine) usually in a solvent such as acetonitrile, benzene, etc., preferably at 20-30 deg.C.
|
