REDUCING AGENT OF SUBSTITUTED ALUMINUM HYDRIDE TYPE

摘要

NEW MATERIAL:A compound shown by the formula I (M is alkali metal; R<1> is alkyl; R<2> is alkyl which may be replaced with halogen or aryl which may be replaced with halogen, trihalogenomethyl or alkyl). EXAMPLE:Sodium hydride bis(2-methoxyethoxy)(hexafluoroisopropoxy)aluminum. USE:A reducing agent especially useful for reducing carbonyl group to give stereospecific hydroxyl group, for example, it is used for reducing carbonyl group at the 15-position in prostaglandin synthesis. PREPARATION:A compound shown by the formula II is reacted with a compound shown by the formula R<2>-OH in a ratio of the latter to the former of usually 0.5-1.5mol to 1mol preferably in a solvent approximately at 0 deg.C.