| 摘要 |
<p>NEW MATERIAL:A compound shown by the formula I [A is group shown by the formula -NHCO-, -NHCOCH=CH-, etc.; R1 and R2 are H or protecting group; R3 is H or methoxy; X is H, OH, halogen, etc.; n is 1 or 2; Y is group shown by the formula II (M is H, etc.); R4 and R5 are H or bonded to form another direct bond; Z is carbonyl, etc.]. EXAMPLE:7-{2-[2-Amino-1,3-thiazol-4-yl]-2-[3-(3,4-dihydroxybenzylidene )carbazo yl]methoxyiminoacetamide}-3-acetoxymethyl-3-cephem-4-carboxylic acid hydro chloride. USE:Penicillin and cephalosporin antibiotic. Useful against Gram-positive and Gram-negative bacteria, Pseudomonas aeruginosa, etc. PREPARATION:A compound shown by the formula III is reacted with a novel carboxylic acid shown by the formula IV or its reactive derivative in a solvent such as chloroform, etc., and optionally deprotected to give a compound shown by the formula I.</p> |
