| 摘要 |
<p>PURPOSE:To produce the optical active isomer of the titled compound useful as an intermediate for various prostanoid (medicine) and pyrethroidal insecticide, economically, by carrying out the direct optical resolution of an oxy cyclopentenone compound using a separation agent containing a polysaccharide as an active component. CONSTITUTION:A mixture of enantiomer of the compound of formula [R<1> and R<2> are H or 1-10C alkyl (which may have aromatic group); R<2> may be 1-10C unsaturated alkyl (which may have aromatic group); X is OH or OR<3>; R<3> is protective group] is subjected to direct optical resolution by the use of a separation agent containing a polysaccharide (preferably homoglycan having high regularity or cellulose, amylose, beta-1,4-chitosan, chitin, beta-1,4-mannan, etc., from which a high-purity polysaccharide can be produced easily) or its derivative as an active component. An optically active isomer of the compound of formula can be produced economically from an inexpensive raw material by a simple chemical conversion technique and a simple chromatographic process.</p> |
