COMPOSITIONS COMPRISING PEPSTATIN AND AN HISTAMINE H2-RECEPTOR ANTAGONIST HAVING AN ENHANCED ANTIULCER ACTIVITY

摘要

Enhanced antiulcer activity is obtained in warm-blooded animals by the concomitant administration of the pepsin complexing agent, pepstatin, and an histamine H2-receptor antagonist of the formula wherein A, m, Z, n, R<1> and R<2> are as defined herein. Concomitant administration of the two entities reduces the amount of histamine H2-receptor antagonist necessary for treatment, thereby decreasing its side-effect liability.