NOVEL PRODUCTION OF DEXTROROTARY OPTICAL ISOMER OF YM-09730 DIASTEREOMER A

摘要

A dextrorotatory optical isomer of diastereomer A of (±-2, 6- dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate3-(1- benzylphrrolidine-3-yl)ester-5-methyl ester of formula (I) or its pharmaceutically accptable acid addn. salt is prepd. by reacting 5- methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4dihydropyridine-3- carboxylic acid with 1-benzyl-3-hydroxypyrrolidine in an org. solvent i.e. CH2Cl2 and DMFA, and pref. sepg. dextrorotatory optical isomer by column chromatography or fractional crystn.. The HCl salt of (I) shows 223-230 deg. C of mp.