INKLUSIONSKOMPLEX AV PROSTACYKLIN-METYLESTER OCH BETA-CYKLODEXTRIN, SETT FOR DESS FRAMSTELLNING SAMT LEKEMEDELSBEREDNING BASERAD DERPA

摘要

Prostacyclin and prostacyclin derivatives form inclusion complexes with cyclodextrins. The complexes may be prepared by contacting an aqueous solution of the cyclodextrin with prostacyclin or a derivative thereof, preferably in organic solvent solution. The inclusion complexes have an improved stability, especially in aqueous solution, compared to the uncomplexed compounds and are extremely potent in inhibiting thrombus formation and inducing the disaggregation of thrombi already formed. The complexes can be formulated into pharmaceutical compositions in conventional manner.