| 摘要 |
<p>Compounds of general formula (I) have antimalarial activity, wherein X represents a halogen or halogen-substituted alkyl group; Y represents CH or N; and R?1 and R2¿, which may be the same or different, represent hydrogen, aminoalkyl, mono- or di-alkylaminoalkyl, mono- or di-(substituted alkyl)aminoalkyl, mono- or di-(cycloalkyl)aminoalkyl, mono- or di-(aryl)aminoalkyl, mono- or di-(substituted aryl)aminoalkyl, or alkyl substituted by a nitrogen-containing heterocyclic or mono- or di-alkyl-substituted heterocyclic group; provided that R?1 and R2¿ are not both hydrogen; and that R2 is not diethylaminomethyl when X is chloro, Y is CH and R1 is hydrogen; or when X is bromo, Y is N and R1 is hydrogen. Processes for the preparation of these compounds are also disclosed.</p> |
