POLYCYCLIC HYDRAZONES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE

摘要

Novel polycyclic hydrazones, processes for their manufacture, pharmaceutical compositions containing them, and their use. Novel hydrazones derived from 3-formylrifamycin S or SV as the aldehydo component and a bi- or tri-cyclic N-aminopiperazine as the hydrazino component and having the formula < IMG > (I) in which R1, R2, R3, R4, R5 and R6, independently of one another, each represents a hydrogen atom or C1-4-alkyl, m and n, independently of one another, each represents an integer from 0 to 5, X represents C1-5-alkylidene, benzylidene or C1-4-alkoxymethylene, Y represents C1-5-alkylidene, C1-4-alkoxymethylene, oxy, thio or optionally substituted imino of the formula -N(R)-wherein R represents hydrogen, C1-4-alkyl, C3-5-alkenyl, C3-12-cycloalkyl or phenyl, or X and Y together represent 1,2-cycloalkylene or ophenylene each of which can be substituted by from one to three C1-4-alkyl radicals, and Rif represents a radical of rifamycin S or SV that is bonded in the 3-position by the free valency, are distinguished by a high and long-lasting antituberculotic activity. They are manufactured in conventional manner, for example by condensation of their components.