发明名称 |
[1,3]oxazino[4,3-a]-isoquinoline derivatives and pharmaceutical compositions containing them |
摘要 |
The invention relates to new [1,3]oxazino[4,3-a]-isoquinoline derivatives of the formula (I) <IMAGE> (I) wherein R1 and R2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is hydrogen, alkyl having from 1 to 8 carbon atoms, cycloakyl or cycloalkenyl having from 3 to 6 carbon atoms, optionally substituted phenyl, aralkyl having from 1 to 4 carbon atoms in the alkyl moiety or heteroaryl, R4 is hydrogen or alkyl having from 1 to 4 carbon atoms, or R3 and R4 together form a -(CH2)n- group, in which n is an integer from 3 to 7, R5 is hydroxyl, halogen or an <IMAGE> group, in which R6 is optionally substituted phenyl, X is oxygen or sulfur, and salts thereof. According to another aspect of the invention there is provided a process for the preparation of these compounds. Compounds of formula (I) are pharmaceutically active. Pharmaceutical compositions containing them are also within the scope of the invention.
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申请公布号 |
US4623647(A) |
申请公布日期 |
1986.11.18 |
申请号 |
US19840664844 |
申请日期 |
1984.10.25 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T. |
发明人 |
BERNATH, GABOR;KOBOR, JENOE;FOELOEP, FERENC;SOHAR, PAL;PERJESI, PAL;EZER, ELEMER;HAJOS, GYOERGY;PALOSI, EVA;DENES, LASZLO;SZPORNY, LASZLO |
分类号 |
A61K31/535;A61P1/04;A61P25/04;A61P25/24;A61P25/26;A61P29/00;A61P37/06;C07D498/04;C07D498/10;(IPC1-7):A61K31/535;C07D265/34 |
主分类号 |
A61K31/535 |
代理机构 |
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地址 |
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