| 摘要 |
NEW MATERIAL:A compound shown by the formula I {R<1> is (CH2)mOR<3> [R<3> is H, CH2CH(OH)CH2OCH2CH3, CH2CH(OAC)CH2OCH2CH3 or CH2OCH2CH2 OCH3; m is 1-4], CH(CH3)CH2OCR<3>, CH=CHCOOR<4> (R<4> is H or lower alkyl), (CH2)nCOOR<4> (n=1-3), etc.; R<4> is 4-lower alkylpiperazino group, 4-lower alkylhomopiperazino group or Y-(CH2)lNR<5>R<6> (Y is HN, O, etc.; R<5> and R<6> are lower alkyl; l is 5-6)}. EXAMPLE:11-( 2-Dimethylaminoethyl )thio-6, 11-dihydrodibenz[b,e]oxepin acetic acid methyl ester. USE:Useful as a drug having antiallergic action. PREPARATION:For example, a compound shown by the formula II is reacted with thionyl chloride and reacted with a compound shown by the formula III to give a compound shown by the formula Ia among compounds shown by the formula I. |
