PRODUCTION OF DIPHENYL THIOETHER DERIVATIVE

摘要

PURPOSE:To obtain the titled compound useful as a synthetic intermediate for dibenzothiepin derivatives simply at a low cost, by passing a benzaldehyde compound and a thiophenol compound as raw materials through novel intermediates. CONSTITUTION:A novel compound expressed by formula I (R<1> is H or halogen) is reacted with a compound expressed by formula II (R<2> is lower alkyl or aryl) or a salt thereof to give a novel compound expressed by formula III, which is then subjected to hydrolysis reaction to afford a novel intermediate expressed by formula IV or a salt thereof. The resultant compound expressed by formula IV or salt thereof is treated with hydrogen peroxide in the presence of a base to give the aimed compound, expressed by formula V and useful as a synthetic intermediate for dibenzothiepin derivatives useful as a remedy for schizophrenia. The novel compound expressed by formula I can be obtained from an inexpensive benzaldehyde compound and thiophenol compound and the production process is industrially advantageous.