| 摘要 |
PURPOSE:To obtain the titled preparation having increased dissolution rate, keeping a supersaturated state, by dissolving a slightly soluble drug in an organic solvent capable of dissolving both the slightly soluble drug and a high polymer compound, adding powder or granule insoluble in the solvent, kneading them and removing the solvent. CONSTITUTION:A slightly soluble drug (e.g., chlormadinone acetate) and a high polymer compound (e.g., hydroxypropyl cellulose) are used in a ratio of 1:1, dissolved in an organic solvent (e.g., dichloromethane) capable of dissolving both the substances, at 0-30 deg.C, the solution is kneaded with 10-70W/V% powder or granule (e.g., magnesium aluminate metasilicate) insoluble in the solvent, the solvent is removed by drying under reduced pressure, heat drying, etc., to give the titled preparation. In the preparation, the slightly soluble drug is easily dissolved in digestive organs when the preparation is orally administered and the preparation sustains increase in elution ratio and/or durability of supersaturated state of elution.
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