| 摘要 |
Benzene derivs. I [R1=R5-CO-, halo; R2=OH, halo; R3=C1-12 alkyl, substituted C1-12 alkyl, C2-6 alkenyl; Y=0, S(O)p, CR6R7; Z=0, S(O)p, CR8R9; R5=H, C1-6 alkyl, C3-8 cycloalkyl, halo, C1-4 alkyl, C1-4 alkoxy; R6, R7=H, C1-10 alkyl, Ph, Benzyl; R8, R9=H, C1-10 alkyl, Ph, Benzyl; n=1-10; p=0,1, or 2; D=CN, SCN, etc.! were prepd. Thus, 10.2 g 4-(2-propyl-3,4-dichloro-phenyxy)pentane nitrile in 80 ml dimethyl formamide was treated with 23.27 g sodium azide and 18.97 g NH4Cl. This mixt. was mixed for 2 days under a N-pressure at 120≦̸C and cooled to room temp. to give 47.9g 5-[4-(2-propyl-3,4- dichlorophenoxy)butyl-tetrazole[A!. At 1x10-6M, the compd. [A! gave 94% inhibition of leukotriene D4-induced contractions of guinia pig ileum in vitro.
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