| 摘要 |
PURPOSE:The reaction of a polyalkylene glycol bearing carboxyl groups on both chain terminals with superoxide dismutase give the title enxyme which is stabilized and used as an anti-inflammatory or remedy for myocardiac infarction, because it has a prolonged life in blood flow. CONSTITUTION:A polyalkylene glycol bearing carboxyl groups on both chain terminals and N-hydroxysuccinimide are dissolved in DMF, then dicyclohexylcarbodiimide is added thereto and stood one overnight at room temperature under stirring. Then, superoxide dismutase is allowed to the product to give the objective enzyme having a skeleton in which superoxide dismutase bonds to both chain terminals of the polyalkylene glycol. The molecular weight of polyalkylene glycol is preferably 400-10,000.
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