| 摘要 |
NEW MATERIAL:2-Acetonyloxy-3,4-difluoronitrobenzene. USE:Useful for production of an antimicrobial agent ofloxacine (9-fluoro-3- methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2, 3-dihydro-7H-pyrido[1,2,3-de]-1,4-ben zoxazine-6-carboxylic acid). PREPARATION:2,3,4-Trifluoronitrobenzene is reacted in the presence of a strong base, e.g. potassium hydroxide or sodium hydroxide, in a solvent, e.g. dimethyl sulfoxide or sulfolane, at room temperature, and the resultant product is then reacted with monochloroacetone in the presence of potassium iodine using a deacidifying agent, e.g. potassium cabonate, to afford the titled compound.
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