| 摘要 |
PURPOSE:To provide a carcinostatic agent containing 5,7,4'-trihydroxyisoflavone as an active component and having tumor cell proliferation inhibiting activity and DNA-synthesis inhibiting activity. CONSTITUTION:The objective agent contains 5,7,4'-trihydroxyisoflavone (general name: genistein) as an active component. Genistein is a compound separated from a certain kind of clover (Trifolium subterraneum L.) and is known to have week estrogen activity. It has been found newly that the compound is effective to inhibit the proliferation of tumor cell, the synthesis of DNA and the activity of tyrosine-specific phosphorylase. Coupled with the low acute toxicity, the compound is useful as a carcinostatic agent for the remedy of human and animal cancer, the remedy for diseases caused by the metastasis of cancer and the prevention of relapse of cancer. It is applied at a rate of usually 200-1,000mg daily in 1-4 divided doses.
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